OpenWork

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Local & self-hosted appsDesktop · Cloud · Self-hosted
Free tierOpen source

What you can do

  • OpenWork is a free, open-source desktop app for Windows, Mac and Linux in which an AI agent works on the files in a folder you choose. It is built on OpenCode and adds a window for people who don't use a terminal: chats, approvals for each file change, reusable skills and a built-in browser. You bring your own model, including a local one. An optional cloud service shares skills, connections and models with a team.

Before choosing

  • Sharing with access control, connectors for services such as Gmail or Slack, and scheduled tasks need a sign-in to OpenWork Cloud, a US service, or your own server. New versions appear about once a week, so menus move. Small local models often fail at the multi-step tool use an agent needs.

Locally Uncensored

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Local & self-hosted appsSelf-hosted · Cloud
FreeOpen source

What you can do

  • Locally Uncensored is a free, open-source desktop app for Windows and Linux that runs AI models on your own computer. One program holds a chat window with document questions, image and video generation through ComfyUI, a coding agent and phone access to your own PC. The chat engine is built in, and a first-start wizard downloads a model. The maker also sells hosted graphics cards as LU Cloud.

Before choosing

  • No Mac desktop build. The Windows installer is not code-signed. The starter models offered at first start have their refusals removed; standard models are a separate list. Without a graphics card, answers are slow.

DeepSeek Harness

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Local & self-hosted appsSelf-hosted
FreeOpen source

What you can do

  • DeepSeek's open-source agent harness: runs a coding agent in a web UI, a terminal job or an automation API.

Before choosing

  • Pre-release. Session telemetry is on in feedback-only mode by default; set DSH_TELEMETRY_MODE=DISABLED to turn it off.

Microsoft 365 Copilot

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Web servicesLocal & self-hosted appsCloud · Desktop · Mobile
Free tier

What you can do

  • Microsoft 365 Copilot (recently renamed Microsoft Copilot) is Microsoft's AI assistant for Word, Excel, Outlook, PowerPoint and Teams. Copilot Chat, the web-grounded chat, comes free with eligible Microsoft 365 work or school plans. The paid Microsoft 365 Copilot add-on licence adds in-app drafting and automatic grounding in the organisation's own emails, files and meetings through Microsoft Graph.

Before choosing

  • Only Copilot Chat is free, and even then only for users signed in with a Microsoft Entra work or school account; a personal Microsoft account does not receive Microsoft's enterprise data protection. Automatic grounding in an organisation's own files, emails and meetings needs the paid Microsoft 365 Copilot add-on licence, not Copilot Chat.

Heidelberg AI Desk

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Local & self-hosted appsDesktop · Self-hosted
Free

What you can do

  • Heidelberg AI Desk, made by the curriculum's own team, installs and runs server tools as apps in containers on your own computer. n8n, Gitea, Open WebUI and Ollama are built in at fixed versions, and further apps come from a shelf. It is free, unsigned and an early test version (0.2.0-alpha.8).

Before choosing

  • Early test version (0.2.0-alpha.8): its own pages say many parts do not work properly yet. It has not been tried with a class or on Windows 10, and nobody has looked at its window on a Mac. The Windows installer is unsigned and the macOS programs are not notarized, so Windows warns about an unknown publisher and macOS may refuse to open them at first. The source code is not public. On macOS and Linux you install Podman yourself. Export any work you want to keep.

Fiji

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Local & self-hosted appsDesktop
FreeOpen source

What you can do

  • Fiji is a batteries-included distribution of ImageJ2 that bundles plugins for segmentation, registration, tracking, deconvolution and colocalization analysis, with automatic plugin updates. It runs on Windows, macOS and Linux, reads most microscopy formats via Bio-Formats, and scripts in Python, Groovy, MATLAB and R.

Before choosing

  • License varies by component: Fiji's own code is GPL, the ImageJ2 core is BSD-2-Clause, original ImageJ is public domain, and individual bundled plugins carry their own licenses.

QuPath

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Local & self-hosted appsDesktop
FreeOpen source

What you can do

  • QuPath is open-source software for digital pathology and bioimage analysis, with built-in cell and tissue detection algorithms, interactive machine-learning classifiers, and whole-slide image support via Bio-Formats and OpenSlide. It runs on Windows, macOS and Linux and scripts in Groovy, but it is explicitly not for clinical, diagnostic or therapeutic use.

Before choosing

  • QuPath states it is not intended for clinical, diagnostic or therapeutic purposes.

napari

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Local & self-hosted appsDesktop · Self-hosted
FreeOpen source

What you can do

  • napari is an open-source Python viewer for n-dimensional scientific images, built for exploring, annotating and combining large microscopy datasets with computational analysis in points, shapes and labels layers. A plugin ecosystem on napari hub adds segmentation, tracking and other domain-specific tools.

Before choosing

  • napari is a Python library and desktop app you install yourself; there is no hosted cloud version.

Cellpose

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Local & self-hosted appsDevelopment & infrastructureDesktop · Self-hosted · Cloud
FreeOpen source

What you can do

  • Cellpose is an open-source generalist model for segmenting cells and nuclei in microscopy images, distributed as a Python package with a drag-and-drop GUI. The current Cellpose-SAM model runs on CPU or GPU, handles 3D volumes, and supports human-in-the-loop retraining on images the base model gets wrong.

Before choosing

  • GPU is optional but recommended; segmenting many images on CPU alone is slow.

Clipchamp

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Web servicesLocal & self-hosted appsCloud · Desktop
Free tier

What you can do

  • Clipchamp is Microsoft's browser-based video editor, with a companion Windows desktop app, AI subtitles in 80+ languages, an AI voiceover generator and background removal. The free plan exports up to 1080p; a Microsoft 365 subscription unlocks 4K export and the premium stock library.

Before choosing

  • The iOS app was retired on 9 June 2026 and there was never an Android app; Clipchamp now runs only in the browser and as a Windows desktop app.

DeepL

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Web servicesLocal & self-hosted appsCloud · Desktop · Mobile
Free tier

What you can do

  • DeepL is a machine translation and writing-assistant service with a web translator, the DeepL Write editing tool, desktop apps, browser extensions and mobile apps. The free plan translates text and one document a month in the browser; paid Pro plans raise the limits, add glossaries, and guarantee submitted text is deleted after translation rather than used for training.

Before choosing

  • Free-plan text is used to train DeepL's models; only paid Pro plans guarantee no training and deletion of submitted text after translation.

AFFiNE

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Web servicesLocal & self-hosted appsCloud · Desktop · Mobile · Self-hosted
Free tierOpen source

What you can do

  • A local-first workspace that combines documents, whiteboards, collections, and collaboration with cloud, desktop, mobile, and self-hosted options.

Before choosing

  • The repository has directory-specific licence terms, and self-hosting requires Postgres, Redis, storage, backups, HTTPS, and upgrades.

Activepieces

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Web servicesLocal & self-hosted appsCloud · Self-hosted
Free tierOpen source

What you can do

  • Visual workflow automation with AI agents, tables, APIs, MCP servers, and app integrations; cloud-hosted or self-hosted.

Before choosing

  • The open-source core is not equivalent to the separately licensed enterprise components; self-hosting requires ongoing infrastructure, credential, storage, backup, and upgrade administration.
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Kiro

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Web servicesLocal & self-hosted appsCloud · Desktop
Free tier

What you can do

  • A coding and agent product supporting IDE, CLI, web, Crew, ACP, and software-development automation workflows.

Before choosing

  • The Free tier includes 50 credits; prompts, task execution, refinements, and hooks consume credits.
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Control Center

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Local & self-hosted appsDesktop
FreeOpen source

What you can do

  • A local-first desktop business dashboard for updates, brand mentions, newsletters, audience totals, reminders, and tasks.

Before choosing

  • The source defaults to a local loopback app; optional model API costs are separate.
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Greptile

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Web servicesLocal & self-hosted appsCloud · Self-hosted
Free tier

What you can do

  • Codebase-aware pull-request review with repository and credit-based review plans.

Before choosing

  • Self-hosting is listed under Enterprise; plan details can change.

Momen

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Web servicesLocal & self-hosted appsCloud · Self-hosted
Free tier

What you can do

  • Turn an app idea into screens, a database and working logic with AI and a visual editor.

Before choosing

  • Free is preview-only; publishing is paid. BYOC/on-premises requires vendor contact, not a public installer. Check permissions, export and data terms before sharing.
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Devin Desktop

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Local & self-hosted appsCloud
Free tier

What you can do

  • Use Cascade to plan and apply multi-file changes inside a VS Code-based editor.

Before choosing

  • The editor needs coding basics, and its free agent quota is limited.

Stable Diffusion 3.5 + ComfyUI

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Local & self-hosted appsSelf-hosted
Free

What you can do

  • Build repeatable image workflows by connecting generation, ControlNet, LoRA, and upscaling nodes.

Before choosing

  • The license has revenue conditions, and ComfyUI requires learning its node graph.

OpenHands

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Web servicesLocal & self-hosted appsCloud · Self-hosted
Free tierOpen source

What you can do

  • Run an autonomous coding agent that plans and applies repository changes.

Before choosing

  • Use a sandbox because an unsandboxed agent server can access your filesystem.
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opencode + voice

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Local & self-hosted appsSelf-hosted
Free

What you can do

  • Drive opencode hands-free by speaking commands into a local voice pipeline.

Before choosing

  • This combines separately maintained community projects rather than an official opencode feature.
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opencode

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Local & self-hosted appsSelf-hosted
BYOKOpen source

What you can do

  • Use a terminal, desktop app, or IDE extension to work with coding agents.

Before choosing

  • Bring your own provider access and monitor its token usage.
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openclaw

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Local & self-hosted appsSelf-hosted
Free tier

What you can do

  • Run a personal agent that you reach through familiar messaging apps.

Before choosing

  • Setup needs Node 24+, an LLM API key, and a local host machine.

Open WebUI

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Local & self-hosted appsSelf-hosted
Free tier

What you can do

  • Give configured local or hosted model endpoints a self-hosted browser interface.

Before choosing

  • It does not supply model capacity; storage, provider configuration, updates and licence conditions remain operational work.