Tools

OpenWork is a free, open-source desktop app for Windows, Mac and Linux in which an AI agent works on the files in a folder you choose. It is built on OpenCode and adds a window for people who don't use a terminal: chats, approvals for each file change, reusable skills and a built-in browser. You bring your own model, including a local one. An optional cloud service shares skills, connections and models with a team.

Desktop · Cloud · Self-hosted · Free tier

Locally Uncensored is a free, open-source desktop app for Windows and Linux that runs AI models on your own computer. One program holds a chat window with document questions, image and video generation through ComfyUI, a coding agent and phone access to your own PC. The chat engine is built in, and a first-start wizard downloads a model. The maker also sells hosted graphics cards as LU Cloud.

Self-hosted · Cloud · Free

DeepSeek's open-source agent harness: runs a coding agent in a web UI, a terminal job or an automation API.

Self-hosted · Free

Jev is TypeSafe AI's hosted System One model for making typed decisions inside software. Give it text or structured text state and narrow Choice, Score or Noul questions; it returns probabilities for routing, classification and scoring. It does not generate prose or code and cannot replace a chat or coding-agent LLM. The documented Jev 1.13 version is available through TypeSafe's API in early access. Start with a decision in your own workflow and keep the final action in your application code.

Cloud · Paid

Supabase is an open-source platform built on PostgreSQL that gives an app a database, sign-in, an automatic API, file storage and a web dashboard called Studio. Row-level security policies decide which rows each signed-in person may read or change. It runs as a managed cloud service or self-hosted with Docker on your own server, and app builders such as Lovable are built to work with it.

Cloud · Self-hosted · Free tier

Microsoft 365 Copilot (recently renamed Microsoft Copilot) is Microsoft's AI assistant for Word, Excel, Outlook, PowerPoint and Teams. Copilot Chat, the web-grounded chat, comes free with eligible Microsoft 365 work or school plans. The paid Microsoft 365 Copilot add-on licence adds in-app drafting and automatic grounding in the organisation's own emails, files and meetings through Microsoft Graph.

Cloud · Desktop · Mobile · Free tier

Heidelberg AI Desk, made by the curriculum's own team, installs and runs server tools as apps in containers on your own computer. n8n, Gitea, Open WebUI and Ollama are built in at fixed versions, and further apps come from a shelf. It is free, unsigned and an early test version (0.2.0-alpha.8).

Desktop · Self-hosted · Free

Biopython is an open-source Python library for computational molecular biology, with modules for sequence handling (Bio.Seq/SeqIO), BLAST search wrappers, protein structure analysis (Bio.PDB), phylogenetics (Bio.Phylo) and NCBI Entrez access. It installs with pip and drops into any Python script, pipeline or notebook.

Desktop · Self-hosted · Cloud · Free

AlphaFold Server is a free web interface to Google DeepMind's AlphaFold 3 model for predicting biomolecular structures, covering proteins, DNA, RNA, common ligands, metal ions and chemical modifications. It is restricted to non-commercial use by individuals and academic or non-profit organisations, capped at 30 jobs per user per day, and outputs may not be used to train competing structure-prediction models.

Cloud · Free

Fiji is a batteries-included distribution of ImageJ2 that bundles plugins for segmentation, registration, tracking, deconvolution and colocalization analysis, with automatic plugin updates. It runs on Windows, macOS and Linux, reads most microscopy formats via Bio-Formats, and scripts in Python, Groovy, MATLAB and R.

Desktop · Free

QuPath is open-source software for digital pathology and bioimage analysis, with built-in cell and tissue detection algorithms, interactive machine-learning classifiers, and whole-slide image support via Bio-Formats and OpenSlide. It runs on Windows, macOS and Linux and scripts in Groovy, but it is explicitly not for clinical, diagnostic or therapeutic use.

Desktop · Free

napari is an open-source Python viewer for n-dimensional scientific images, built for exploring, annotating and combining large microscopy datasets with computational analysis in points, shapes and labels layers. A plugin ecosystem on napari hub adds segmentation, tracking and other domain-specific tools.

Desktop · Self-hosted · Free

Cellpose is an open-source generalist model for segmenting cells and nuclei in microscopy images, distributed as a Python package with a drag-and-drop GUI. The current Cellpose-SAM model runs on CPU or GPU, handles 3D volumes, and supports human-in-the-loop retraining on images the base model gets wrong.

Desktop · Self-hosted · Cloud · Free

PubMed is the free biomedical literature database run by the US National Library of Medicine. Its Best Match relevance sort uses a machine-learning model on top of term-frequency ranking, and results export to citation managers, plain text, XML or CSV without needing an account; a free My NCBI account adds saved searches and email alerts.

Cloud · Free

Clipchamp is Microsoft's browser-based video editor, with a companion Windows desktop app, AI subtitles in 80+ languages, an AI voiceover generator and background removal. The free plan exports up to 1080p; a Microsoft 365 subscription unlocks 4K export and the premium stock library.

Cloud · Desktop · Free tier

DeepL is a machine translation and writing-assistant service with a web translator, the DeepL Write editing tool, desktop apps, browser extensions and mobile apps. The free plan translates text and one document a month in the browser; paid Pro plans raise the limits, add glossaries, and guarantee submitted text is deleted after translation rather than used for training.

Cloud · Desktop · Mobile · Free tier

Compare responses from multiple AI models in one paid cloud app using one-click reprompting. Draft with uploaded documents, organise chats in projects, search the web, and generate images or videos within plan-dependent usage limits.

Cloud · Paid

An open-source code-review CLI that reads Git diffs or whole files and produces structured, line-level review comments using a configurable language model or a host coding agent.

Desktop · Self-hosted · Bring your own key

Ornith-1.5-35B-A3B is an open-weight reasoning model for coding, repository work and agents that call tools. Its Qwen3.5-family mixture-of-experts architecture contains about 35 billion parameters but activates roughly 3 billion per token. Ornith describes training that jointly improves task generation, agent scaffolds and solutions through reinforcement learning. The published context window is 262,144 tokens. It is a candidate for developers who want to run a coding assistant on their own infrastructure: the official card documents vLLM and SGLang servers with OpenAI-compatible APIs, plus GGUF use through Ollama or llama.cpp. Start with a small repository task and check the result against your tests before expanding its role.

Self-hosted · Free

A local-first workspace that combines documents, whiteboards, collections, and collaboration with cloud, desktop, mobile, and self-hosted options.

Cloud · Desktop · Mobile · Self-hosted · Free tier

Visual workflow automation with AI agents, tables, APIs, MCP servers, and app integrations; cloud-hosted or self-hosted.

Cloud · Self-hosted · Free tier

MiniCPM5-2B

A compact OpenBMB text model with downloadable weights, tool calling and several local runtime formats.

Self-hosted · Desktop · Free

Artlist AI Flows

A hosted visual canvas for reusable, node-based AI generation flows across connected media steps.

Cloud · Paid

Bolt.new

Build a web prototype through prompts, code editing and preview, with GitHub sync and integrated hosting.

Cloud · Free tier